Package: DTEBOP2
Title: Bayesian Optimal Phase II Randomized Clinical Trial Design with
        Delayed Outcomes
Version: 1.0.3
Authors@R: c(
      person("Zhongheng", "Cai", email = "zhonghengcai123@gmail.com", role = c("aut", "cre")),
      person("Haitao", "Pan", email = "Haitao.Pan@STJUDE.ORG", role = "aut")
    )
Description: Implements a Bayesian Optimal Phase II design (DTE-BOP2)
        for trials with delayed treatment effects, particularly
        relevant to immunotherapy studies where treatment benefits may
        emerge after a delay. The method builds upon the BOP2 framework
        and incorporates uncertainty in the delay timepoint through a
        truncated gamma prior, informed by expert knowledge or default
        settings. Supports two-arm trial designs with functionality for
        sample size determination, interim and final analyses, and
        comprehensive simulation under various delay and design
        scenarios. Ensures rigorous type I and II error control while
        improving trial efficiency and power when the delay effect is
        present. A manuscript describing the methodology is under
        development and will be formally referenced upon publication.
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.3.2
Imports: truncdist, doParallel, foreach, parallel, invgamma
Suggests: knitr, rmarkdown, survRM2adapt, ggplot2, reconstructKM,
        survival, survminer
LazyData: true
VignetteBuilder: knitr
NeedsCompilation: no
Packaged: 2026-09-20 11:45:26 UTC; root
Author: Zhongheng Cai [aut, cre], Haitao Pan [aut]
Maintainer: Zhongheng Cai <zhonghengcai123@gmail.com>
Depends: R (>= 3.5.0)
Repository: https://zhongheng-biostatistics.r-universe.dev
Date/Publication: 2025-05-09 10:40:06 UTC
RemoteUrl: https://github.com/cran/DTEBOP2
RemoteRef: HEAD
RemoteSha: 82a8d2be82a62dcad096a2bcfb2fb1af0f761d7e