# --------------------------------------------
# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
# --------------------------------------------
 
cff-version: 1.2.0
message: 'To cite package "DTEBOP2" in publications use:'
type: software
license: GPL-3.0-only
title: 'DTEBOP2: Bayesian Optimal Phase II Randomized Clinical Trial Design with Delayed
  Outcomes'
version: 1.0.3
doi: 10.32614/CRAN.package.DTEBOP2
abstract: Implements a Bayesian Optimal Phase II design (DTE-BOP2) for trials with
  delayed treatment effects, particularly relevant to immunotherapy studies where
  treatment benefits may emerge after a delay. The method builds upon the BOP2 framework
  and incorporates uncertainty in the delay timepoint through a truncated gamma prior,
  informed by expert knowledge or default settings. Supports two-arm trial designs
  with functionality for sample size determination, interim and final analyses, and
  comprehensive simulation under various delay and design scenarios. Ensures rigorous
  type I and II error control while improving trial efficiency and power when the
  delay effect is present. A manuscript describing the methodology is under development
  and will be formally referenced upon publication.
authors:
- family-names: Cai
  given-names: Zhongheng
  email: zhonghengcai123@gmail.com
- family-names: Pan
  given-names: Haitao
  email: Haitao.Pan@STJUDE.ORG
repository: https://zhongheng-biostatistics.r-universe.dev
commit: 82a8d2be82a62dcad096a2bcfb2fb1af0f761d7e
date-released: '2025-05-09'
contact:
- family-names: Cai
  given-names: Zhongheng
  email: zhonghengcai123@gmail.com